Prevention and treatment of bacterial infection by the recombinant human granulocytic colony-stimulating factor in newborns
Estrin, V.V.; Efanov, E.A.; Pukhtinskaia, M.G.
Anesteziologiia i Reanimatologiia 2004(3): 43-45
2004
ISSN/ISBN: 0201-7563 PMID: 15314859 Document Number: 583015
An impact on the immune system is a principally new trend in optimizing the prevention and treatment of neonatal sepsis. The purpose of the case study was to investigate the clinical efficiency of neipogene. The study comprised 33 mature newborns with respiratory pathology and perinatal CNS lesion, who were at the artificial lung ventilation (ALV). Neipogene was found to increase for a short time period the absolute number of neutrophils, monocytes and the pool of stem cells (predecessors of the myeloid row) in peripheral blood, which cut the rate of sepsis, lethality, ALV time and treatment costs. The conclusion is that neipogene is safe and effective for the prevention and treatment of bacterial complications.