Top Abstract Purchase Related
Home
>
Node
>
Subnode

The relationship between expression of p53/bcl-2 and clinicopathological criteria in endometrioid adenocarcinomas of the endometrium

Sari, I.; Gocmen, A.; Bitiren, M.; Cakmak, E.A.

European Journal of Gynaecological Oncology 25(1): 79-80

2004

ISSN/ISBN: 0392-2936
PMID: 15053067
Document Number: 580576
Objective: Thirty patients with endometrioid adenocarcinomas of the endometrium who had undergone total abdominal hysterectomy and bilateral salpingo-oophorectomy were reviewed histopathologically. Materials and Methods: Tissues were stained immunohistochemically with p53 and bcl-2, respectively. Ten cases were selected as grade 1, ten cases grade 2 and ten cases grade 3. Results: We observed 14 cases (46.6%) of bcl-2 and four cases (13.3%) of p53 positivity; p53 expression showed an opposite correlation to bcl-2 staining, estrogen and progesterone. Conclusion: We observed a decrease in bcl-2 reactivity and an increase in p53 positive staining as the histological differentiation worsened.

Document emailed within 1 workday
Secure & encrypted payments

Xiong, Y.; Xiong, Y.Y.; Zhou, Y.F. 2010: Expression and significance of beta-catenin, Glut-1 and PTEN in proliferative endometrium, endometrial intraepithelial neoplasia and endometrioid adenocarcinoma European Journal of Gynaecological Oncology 31(2): 160-164
Kolosov, A.E.; Chernina, L.A.; Bychkov, V.M. 1983: Ultrastructural characteristics of endometrioid and serous ovarian adenocarcinomas Arkhiv Patologii 45(8): 34-38
Zhan, J.; Liu, J-ping.; Zhu, Z-hua.; Yao, H-rui.; Chen, C-yan. 2004: Relationship between COX-2 expression and clinicopathological features of colorectal cancers Chinese Medical Journal 117(8): 1151-1154
Nasrabadi, N.N.; Sargazi, F.; Shokrzadeh, M.; Abediankenari, S.; Hoseini, S.V.; Najafi, M.; Haghi-Aminjan, H.; Mirmajidi, S.H.; Ataee, R. 2018: Expression of MT1 receptor in patients with gastric adenocarcinoma and its relationship with clinicopathological features Neuro Endocrinology Letters 39(2): 111-118
Yu, L.; Shen, Y.; Li, J.-K.; Sun, Y.-H.; Wang, Y.-C.; Zhang, J.-H. 2008: Expression of chemokine receptor CXCR4 in colorectal carcinoma and its relationship with clinicopathological parameters Zhonghua Wei Chang Wai Ke Za Zhi 11(5): 482-486
Ren, T.-w.; Zhou, Y.-n.; Wu, J.; Zhang, Z.-y.; Hao, T.-j.; Wang, J.-x.; Zou, S.-j.; Chen, Z.-f.; Huang, S.-S.; Zhang, L.-H.; Zhao, Y. 2009: Relationship between Ets-1 expression and angiogenesis, clinicopathological features and survival of patients with gastric carcinoma Zhonghua Zhong Liu Za Zhi 31(9): 674-678
Zhang, B.; Liu, F.-f.; Ma, Y.-j.; Gu, F. 2013: Cytoplasmic expression of aquaporin-1 in breast cancer cells and its relationship with clinicopathological characteristics and prognosis Zhonghua Zhong Liu Za Zhi 35(12): 904-909
Chen, D.; Jin, Z.; Xing, F. 1998: The expression of integrin beta 3 in cycling and early pregnant endometrium and its relationship with primary unexplained infertility Zhonghua Fu Chan Ke Za Zhi 33(8): 487-489
Geisler, J.P.; Wiemann, M.C.; Zhou, Z.; Miller, G.A.; Geisler, H.E. 1996: Using FIGO histologic grade to determine when to perform lymphadenectomies in endometrioid adenocarcinoma of the endometrium European Journal of Gynaecological Oncology 17(3): 204-207
Li, Y.; Zhang, S.; Xu, L. 2014: Expression of nerve growth factor produced by ectopic endometrium from patients with adenomyosis and its relationship with pain scales and innervation Zhonghua Fu Chan Ke Za Zhi 49(2): 120-124
Edinger, D.D.; Jelen, I.; Granai, C.; Anderson, B. 1983: Tracheloscopically directed biopsy of the endocervical canal in stage II adenocarcinomas of the endometrium European Journal of Gynaecological Oncology 4(1): 6-8
Mourtzikou, A.; Kosmas, K.; Marouga, A.; Stamouli, M.; Pouliakis, A.; Karakitsos, P. 2012: The Use of an Immunocytochemical Double-Labeling Staining Can Display the Distribution of Bcl-2/Ki-67 Cells in Endometrial Adenocarcinomas as well as in Normal Endometrium Clinical Laboratory 58(1-2): 133-144
Park, H.; Seok, J.M.; Yoon, B.S.; Seong, S.J.; Kim, J.Y.; Shim, J.Y.; Park, C.T. 2012: Effectiveness of high-dose progestin and long-term outcomes in young women with early-stage, well-differentiated endometrioid adenocarcinoma of uterine endometrium Archives of Gynecology and Obstetrics 285(2): 473-478
Hampton, A.L.; Rogers, P.A.; Affandi, B.; Salamonsen, L.A. 2001: Expression of the chemokines, monocyte chemotactic protein (MCP)-1 and MCP-2 in endometrium of normal women and Norplant users, does not support a central role in macrophage infiltration into endometrium Journal of Reproductive Immunology 49(2): 115-132
Brück, P.; Vilches Cisneros, N.; Ramos López, E.; Barboza Quintana, O.; Ancer Rodríguez, J.ús.; Flores Gutiérrez, J.P. 2006: Her2-Neu expression in ductal adenocarcinomas of the breast gland: correlation with histopathological parameters and estrogen receptors' expression in Mexican patients Ginecologia y Obstetricia de Mexico 74(10): 516-522
Dvalishvili, I.; Charkviani, L.; Charkviani, T.; Turashvili, G.; Burkadze, G. 2005: Clinical prognostic factors and expression of cathepsin D in endometrioid adenocarcinoma Georgian Medical News 126: 27-31
Mylonas, I.; Mayr, D.; Walzel, H.; Shabani, N.; Dian, D.; Kuhn, C.; Kunze, S.; Jeschke, U.; Friese, K. 2007: Mucin 1, Thomsen-Friedenreich expression and galectin-1 binding in endometrioid adenocarcinoma: an immunohistochemical analysis Anticancer Research 27(4a): 1975-1980
Zámečník, M.; Bartoš, P.; Kaščák, P. 2015: Shadow cell differentiation in endometrioid carcinomas of the uterus. its frequent occurrence and beta-catenin expression Ceskoslovenska Patologie 51(3): 123-126
Suren, D.; Arda Gokay, A.; Sayiner, A. 2018: High Mobility Group Box 1 (HMGB1) expression in gastric adenocarcinomas Journal of BUON: Official Journal of the Balkan Union of Oncology 23(2): 422-427
Buchynska, L.G.; Nesina, I.P.; Kashuba, E.V. 2007: Different trends of p53, MDM2 and p14 ARF expression patterns in endometrial adenocarcinomas versus hyperplasia Experimental Oncology 29(4): 287-294