The expression of integrin beta 3 in cycling and early pregnant endometrium and its relationship with primary unexplained infertility
Chen, D.; Jin, Z.; Xing, F.
Zhonghua Fu Chan Ke Za Zhi 33(8): 487-489
1998
ISSN/ISBN: 0529-567X PMID: 10806750 Document Number: 495128
To profile the changes in integrin beta 3 expression in cycling and early pregnant endometrium and its relationship with unexplained infertility. Expression of integrin beta 3 on endometrium was detected in 56 normal cycling women during different menstrual phases or early pregnant women, and 9 cases with unexplained infertility during mid-luteal phase by immunohistochemistry technique. Integrin beta 3 was expressed only in the midluteal or pregnant endometrium(after cycle day 19). Compared with normal women, integrin beta 3 failed to express in the midluteal endometrium from women with unexplained infertility. Our findings suggest integrin beta 3 may play important roles in the process of implantation and decidualization. It might be a new reliable marker of uterine receptivity. Abnormal endometrial integrin beta 3 expression might be the major cause of unexplained infertility.