Cellular immunity in patients with urogenital chlamydiosis
Mikolauskas, V.P.
Klinicheskaia Laboratornaia Diagnostika 4: 36-38
2004
ISSN/ISBN: 0869-2084 PMID: 15188743 Document Number: 580461
Abnormalities in the cellular immunity chain (CIC) were found in 63.04% of patients with urogenital chlamydiosis (UGC) within a study of cellular immunity in patients with the above pathology. According to the study results, the below listed were the main CIC impairments: a lack or reaction to the inducer of T-helpers (CD3+ and CD4+), and to activated T-lymphocytes (CD3+ and CD25+); higher counts of cytotoxic T-lymphocytes (CD3+ and CD8+), a higher content of B-lymphocytes (CD3+ and CD19+, and lower counts of NK-cells (CD3- and CD56+). However, research of the lymphocyte subpopulation alone is not enough to evaluate adequately the immune system of a patient. In order to choose an adequate scheme for the treatment of UGH patients it is necessary to undertake a study of the immune status that should comprise, apart CIC investigations, the following: humoral immunity, phagocyte function, factors of non-specific body resistance and cytokine status.