Studies on chiral inversion of dextropantoprazole in human
Xie, Z-yong.; Yang, B-hua.; Zhang, Y-fan.; Zhong, D-fang.
Yao Xue Xue Bao 39(5): 370-373
2004
ISSN/ISBN: 0513-4870 PMID: 15338882 Document Number: 580245
Aim To study the chiral inversion of dextropantoprazole in human. Methods Three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazole. An HPLC method was developed and used to determine the total plasma concentrations of each enantiomer. The ratios of the enantiomers in plasma samples were measured on a Chiral-AGP column. The plasma concentration of each enantiomer was then calculated using the ratios of enantiomers and total concentrations of the two enantiomers previously measured. Results The AUC0-1 of levopantoprazole was only 1.5% of the total AUC0-1 of enantiomers. Conclusion The chiral inversion from dextropantoprazole to levopantoprazole does not occur in the three healthy Chinese male volunteers after an oral dose of 40 mg dextropantoprazol.