Morphoproteomic portrait of the mTOR pathway in mesenchymal chondrosarcoma
Brown, R.E.
Annals of Clinical and Laboratory Science 34(4): 397-399
2004
ISSN/ISBN: 0091-7370 PMID: 15648779 Document Number: 580226
Morphoproteomics is defined as the identification by immunohistochemistry of the molecular circuitry of various proteins in a tumor by noting their state of activation (translocation and phosphorylation) and correlative expressions. Such an approach can uncover or confirm potential molecular targets that may be essential to the growth, integrity, and histogenesis of a particular tumor type and that are amenable to specific therapeutic interventions. This communication illustrates the application of such an approach in depicting the mTOR pathway in mesenchymal chondrosarcoma.