Laboratory diagnostics of enterovirus cardiac infections
Amvros'eva, T..V.; Poklonskaia, N.V.; D'iakonova, O.V.; Kazinets, O.N.; Bogush, Z.F.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 2004(3): 58-62
2004
ISSN/ISBN: 0372-9311 PMID: 15346952 Document Number: 580188
Diagnostic efficacy of different markers of enterovirus cardiac infection (EVCI) has been evaluated. Testing of clinical samples from patients with myocarditis (n=50), dilatation cardiomyopathy (n=122), ischemic heart disease (n=34) and from healthy donors (n=50) revealed diagnostically significant markers in patients suspected for enterovirus cardiac infection: antienterovirus IgM in the patrient's blood serum, the expression of viral proteins by myocardium cells and the presence of genome RNA and replicative intermediate in cardiac cells. The results obtained were used for developing up-to-date scheme of the EVCI diagnosis which included the data from the case history, the preliminary rapid diagnosis and the molecular biological study of the cardiac biopsies.