Allergic family history as a protective determinant to helminthic infection
Sangsupawanich, P.; Chongsuvivatwong, V.; Mo-Suwan, L.; Choprapawon, C.
Journal of the Medical Association of Thailand 96(10): 1310-1312
2013
ISSN/ISBN: 0125-2208 PMID: 24350412 Document Number: 579979
Investigate the resistance to helminths in children with an allergic family history. The study was undertaken as part of the Prospective Cohort Study of Thai Children (PCTC) that followed all births in the year 2001 from rural districts in Thailand. The family histories of allergic diseases were validated by the physicians'diagnoses and medical record reviews. Fresh stool examinations were carried out at 18 to 36 months of age. Of 1,076 live births in the cohort, 659 children had complete information. A family history of allergy presented in 5.4% of the children. The prevalence of any helminthic infection, Ascaris lumbricoides, Trichuris trichiura, and hookworm were 25.0%, 18.2%, 9.2%, and 5.3%, respectively. The adjusted odds ratio of a family history of allergy for helminthic infection was 0.28 (95% CI, 0.08-0.95). A family history of allergic diseases independently increases resistance to helminthic infection.
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