Insulin-like growth factor binding protein 1 (IGFBP-1) in vaginal fluid in pregnancy
Vogel, I.; Grønbaek, H.; Thorsen, P.; Flyvbjerg, A.
In Vivo 18(1): 37-41
2004
ISSN/ISBN: 0258-851X PMID: 15011749 Document Number: 578855
Objective: To examine vaginal insulin-like growth factor binding protein 1 (IGFBP-1) as a marker of preterm delivery, amniotic fluid leakage or vaginal infection. Materials and Methods: The material consisted of a nested case-control study (67 with idiopathic preterm delivery and 406 randomly selected women with term deliveries) from a prospective cohort of 2,846 women. Results: Vaginal npIGFBP-1 was weakly associated with preterm delivery. Elevated npIGFBP-1 gave an increased risk of preterm delivery (OR 2.8 (1.4-6.7)). Elevated IGFBP-1 provided a sensitivity of 13% at a false-positive rate of 4.4% in a low-risk population. When adjusting for other co-variates associated with preterm delivery the association between npIGFBP-1 and preterm delivery disappeared; there was an interaction between alcohol consumption and npIGFBP-1. Conclusion: The current study found vaginal npIGFBP-1 to be weakly associated with gestational age at delivery. However, in this study the association may potentially be explained by alcohol consumption.