Determination of placental protein 12 (insulin-like growth factor binding protein 25) in pleural effusion of various origins

Strache, R.R.; Büttner, H.H.; Göcze, P.; Szabó, D.; Willroth, P.O.; Briese, V.; Csaba, I.

Zeitschrift für die Gesamte Innere Medizin und ihre Grenzgebiete 45(6): 164-166


ISSN/ISBN: 0044-2542
PMID: 1695798
Document Number: 366762
It is reported on the possible role of the radioimmunological estimation of placental protein 12 (PP 12; insulin-like growth factor binding protein 25, IGF-BP 25) in pleural effusions of patients with lung cancer, with pleural carcinosis of extrathoracal carcinomas and benign pleural diseases, respectively. There are more PP 12, IGF-BP 25-positive cases at benign diseases than at carcinomas at all. It is discussed the possible importance of PP 12, IGF-BP 25 as a binding protein of growth factor s IGF-I and -II. The clinical validity should be analysed in more detail on the basis of the estimation of more patients.

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