Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide) , the selective agonist of CB1 receptors
Rutkowska, M.; Jachimczuk, O.
Acta Poloniae Pharmaceutica 61(2): 165-167
2004
ISSN/ISBN: 0001-6837 PMID: 15493300 Document Number: 578800
The antidepressant effect of ACEA (arachidonyl-2-chloroethylamide), a selective agonist of CB1 receptors, and its interaction with fluoxetine were studied in mice. ACEA (1.0 and 2.0 mg/kg i.p.) reduced the immobility time in the forced swimming test and attenuated the head - twitch response to L-5-HTP. The concomitant administration of ACEA (1.0 mg/kg i.p.) and fluoxetine (20 mg/kg i.p.) resulted in the strongest shortening of immobility time, significant in comparison with both ACEA and fluoxetine given alone. The obtained results indicate that ACEA may have antidepressant efficacy and shows a synergistic effect when given with fluoxetine in the forced swimming test.