New evidence for the antidepressant activity of MK-801, a non-competitive antagonist of NMDA receptors
Papp, M.; Moryl, E.
Polish Journal of Pharmacology 45(5-6): 549-553
1993
ISSN/ISBN: 1230-6002 PMID: 8012477 Document Number: 420399
Chronic treatment with MK-801 (0.3 mg/kg ip; 5 weeks) reverses the deficit in rewarded behavior (anhedonia) measured as a decrease in the consumption of a palatable sucrose solution in a chronic mild stress model of depression in rats. The magnitude of this effect was comparable to that observed following similar administration of imipramine (10 mg/kg ip; 5 weeks), used as a standard antidepressant drug.
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