Immune status and proinflammatury cytokines in pregnant women with acute cytomegalovirus infection
Asrankulova, D.B.; Rizopulu, A.P.; Kurbanov, D.D.
Zhurnal Mikrobiologii Epidemiologii i Immunobiologii 4: 84-86
2004
ISSN/ISBN: 0372-9311 PMID: 15481934 Document Number: 576384
A total of 64 pregnant women aged 16-40 years with acute cytomegalovirus (CMV) infection were examined. CMV infection was diagnosed by the detection of anti- CMV IgM (by the enzyme immunoassay) or DNA by PCR in the blood. The immunophenotype of lymphocytes CD3+, CD4+, CD8+, CD16+, CD19+, IgG, IgM, IgA and the spontaneous production of TNFalpha and IL-8 in the blood were studied. In pregnant women with CMV infection the presence of the immunosuppression of cell-mediated immunity reactions, the hyperproduction of Fc-receptors of natural killers, B lymphocytes (CD19+), the hyperglobulinemia of serum IgM and IgG, as well as the increased synthesis of proinflammatory cytokines--TNFalpha and IL-8--were established.