Sinus histiocytosis with massive lymphadenopathy. A newly recognized benign clinicopathological entity
Rosai, J.; Dorfman, R.F.
Archives of Pathology 87(1): 63-70
1969
ISSN/ISBN: 0363-0153 PMID: 5782438 Document Number: 5755
Four cases of a newly recognized benign disease which in the past has been confused with malignant reticuloendotheliosis are described. It is characterized clinically by massive lymphadenopathy, especially of the cervical region, fever, and leukocytosis, and pathologically by a prominent enlargement of lymph nodes due to dilatation of the subcapsular and medullary sinuses, which may progress to total effacement of the architecture. Most of the cells filling the sinuses are non-neoplastic histiocytes, often containing phagocytosed lymphocytes. The disease runs a benign, albeit prolonged, clinical course. The etiology and pathogenesis are unknown.
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