Role of histamine release - a possible mechanism of action of intrauterine contraceptive device
Achari, K.; Achari, G.; Kishore, K.
Journal of Obstetrics and Gynaecology of India 23(4): 463-467
1973
ISSN/ISBN: 0971-9202 PMID: 12307061 Document Number: 57517
The histamine content of the endometrium was estimated in 50 women who were wearing an intrauterine device and in 48 control women. Histological examinations were conducted in both groups. The histamine content was higher among IUD users during all phases of the menstrual cycle. Histologically, endometria which had been exposed to the devices showed leucoytic infiltration and hyperestrogenism. A possible mechanism of action of the IUD is proposed, based on these biochemical and histological changes.
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