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Factors associated with epidemic multiresistant Pseudomonas aeruginosa infections in a hospital with AIDS-predominant admissions

Gomes, M.Zenaide.Ribeiro.; Oliveira, R.Vasconcellos.C.de.; Machado, C.Romero.; Conceição, M.de.Souza.da.; Souza, C.Vieira.de.; Lourenço, M.Cristina.da.Silva.; Asensi, M.Dutra.

Brazilian Journal of Infectious Diseases An Official Publication of the Brazilian Society of Infectious Diseases 16(3): 219-225

2012

ISSN/ISBN: 1413-8670
PMID: 22729187
DOI: 10.1016/s1413-8670(12)70314-8
Document Number: 574708
Infections caused by multiresistant Pseudomonas aeruginosa (MR-PA) have been associated with persistent infections and high mortality in acquired immunodeficiency syndrome (AIDS) patients. Therefore, understanding the predisposing factors for infection/colonization by this agent is critical for controlling outbreaks caused by MR-PA in settings with AIDS patients. and methods To analyze the presence of factors associated with the acquisition of an epidemic MR-PA strain in a hospital with AIDS-predominant admission. A casecontrol study was carried out in which cases and controls were gathered from a prospective cohort of all hospitalized patients in an infectious disease hospital during a five-year study period. Multivariate logistic regression analysis demonstrated that enteral nutrition (OR=14.9), parenteral nutrition (OR=1.7), and use of ciprofloxacin (OR=8.9) were associated with a significant and independent risk for MR-PA acquisition. Although cross-colonization was likely responsible for the outbreaks, the use of ciprofloxacin was also an important factor associated with the acquisition of an epidemic MR-PA strain. More studies are necessary to determine whether different types of nutrition could lead to modification of gastrointestinal flora, thereby increasing the risk for infection/colonization by MR-PA in this population.

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