Expanding the possibilities of using biphosphonates for prophylaxis and treatment of osteal complications in malignant metastasis
Svishchenko, I.A.; Shimanovskiĭ, N.L.
Eksperimental'naia i Klinicheskaia Farmakologiia 67(6): 66-71
2004
ISSN/ISBN: 0869-2092 PMID: 15707020 Document Number: 570740
New results concerning the mechanisms of biphosphonate action on malignant metastasis are described, which justify an increase in the use of biphosphonates not only for the treatment of malignancies, but for prophylaxis of malignant neoplasm development as well. Data on the relationship between the pharmacological effect of biphosphonates and their chemical structure are presented. It is emphasized that clodronate, which is most thoroughly investigated drug of this group, can be more frequently used in clinics for the treatment and prophylaxis of osteal complications in cases of breast cancer.