Pro-inflammatory chemokine IL-8 in gastroesophageal reflux disease
Naito, Y.; Yoshida, N.; Yoshikawa, T.
Nihon Rinsho. Japanese Journal of Clinical Medicine 62(8): 1447-1453
2004
ISSN/ISBN: 0047-1852 PMID: 15344533 Document Number: 570400
Recent reports have demonstrated significantly higher expression levels of interleukin-8 (IL-8) in patients with gastroesophageal reflux disease (GERD) including non-erosive reflux disease (NERD). The levels of IL-8 mRNA expression were significantly decreased after proton pump inhibitor. The esophageal expression of CINCs, rat IL-8-like chemokines, was markedly enhanced in the models of acute or chronic esophagitis in rats. The production of IL-8 from esophageal mucosal cells was enhanced by the exposure to bile acid. These results suggest that IL-8 chemokine may play a major role in the pathogenesis of esophageal inflammation in GERD.