Regurgitation esophagitis treated with Gaviscon
Jakobsen, B.M.; Amdrup, E.
Nordisk Medicin 80(38): 1243-1245
1968
ISSN/ISBN: 0029-1420 PMID: 4301892 Document Number: 5704
Seventy-six patients with symptoms and signs of oesophagitis have been treated with gaviscon, which consists of equivalent amounts of alginic acid and sodium bicarbonate and antacids in the form of aluminum hydroxide and magnesium trisilicate. The action of the drug consists partly in adherence to the mucous membrane of the oesophagus with neutralisation of the acid, and partly in the formation of a gel of high viscosity in the cardiac orifice and fundus of the stomach so that gastro-oesophageal reflux is partly or wholly prevented. A follow-up was carried out in 73 patients ranging in age from 8 to 86 years. The treatment extended over periods of up to 39 months. 41 patients underwent oesophagoscopy, and in 45 the gastric acidity was investigated. In 46 patients (63 %) the effect of the treatment was good, and in 27 (37 %) it had no effect. Among 57 patients with roentgenographically demonstrated hiatus hernia of the sliding type a good effect was achieved with gaviscon in 39 (68 %), and in 18 (32 %) there was no effect. No side-effects were observed with this preparation. No placebo treatment was given.
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