Anesthetic management of a patient with olivopontocerebellar atrophy using heart rate variability (HRV)
Yazawa, R.; Kondo, T.; Miyashita, T.; Koide, Y.; Andoh, T.; Yamada, Y.
Masui. Japanese Journal of Anesthesiology 53(1): 55-58
2004
ISSN/ISBN: 0021-4892 PMID: 14968603 Document Number: 570301
A 65-year-old woman with olivopontocerebellar atrophy (OPCA), manifested with cerebellar ataxia mainly, with coexisting impairment of the autonomic nervous system function, and extrapyramidal symptoms, was scheduled for cholecystectomy. With no premedication, anesthesia was induced with sevoflurane and maintained with 1-1.5% of sevoflurane and 66% of nitrous oxide mixed with oxygen. Heart rate variability (HRV) calculated from ECG was used for a monitor of the autonomic nervous system activity. Before the induction of anesthesia, severe reduction of the HRV parameters suggested that both her sympathetic and parasympathetic nervous activities might have been severely reduced. We considered that the patient might have postganglionic sympathetic nerve hypersensitivity against inotropic agents. When her blood pressure decreased temporarily after the induction of anesthesia, a bolus dose of ephedrine 1 mg wa given intravenously, which stimulated the sympathetic nervous system indirectly, and could increase her blood pressure. Hypotension during anesthesia in a patient with OPCA with severe autonomic nervous failure was successfully treated by a minimal dose of ephedrine.