Interaction of oestradiol and gonadotrophin-releasing hormone on LH release in the mare
Vivrette, S.L.; Irvine, C.H.
Journal of Reproduction and Fertility. Supplement 1979(27): 151-155
1979
ISSN/ISBN: 0449-3087 PMID: 383984 Document Number: 57
Acyclic mares given oestradiol for 3 days to simulate the preovulatory plasma oestradiol surge showed a non-significant 37% decrease in plasma LH during treatment. When GnRH analogue injections were given with oestradiol on Days 1-3, oestradiol had no effect on each GnRH-induced LH increase, but LH increases were more prolonged following subsequent GnRH injections on Days 4-7 when oestradiol was no longer being given. A much greater prolongation of LH release occurred when the course of GnRH injections was commenced after oestradiol treatment ceased; the LH response was almost identical to the prolonged periovulatory LH surge of the normal cycle. Therefore, it appears that the timing of the oestradiol surge, in relation to other hormonal events, is critical in inducing the uniquely prolonged periovulatory LH surge of the mare.
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