Morphological changes in adrenal cortex--the final effect of angiotensin Ii receptor antagonists
Masłyk, T.; Romanowska-Sarlej, J.; Kifer-Wysocka, E.; Matysiak, W.ło.; Czerny, K.
Annales Universitatis Mariae Curie-Sklodowska. Sectio D Medicina 59(2): 129-133
2004
ISSN/ISBN: 0066-2240 PMID: 16146064 Document Number: 569287
The influence of losartan, angiotensin receptor on the histological image of the adrenal glomerular layer of white rats was revealed. The drug was administered in the therapeutic and ten times higher dose. It was manifested by the decrease of glandular cells and prevalence of blastic cells of the cortex. After a 2-month break in drug administration, the reconstruction of glandular cells was noticed, which could indicate that the observed changes are of transitory character.