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Rapidly progressive glomerulonephritis: current and evolving treatment strategies

Little, M.A.; Pusey, C.D.

Journal of Nephrology 17(Suppl): S10-S19

2004

ISSN/ISBN: 1121-8428
PMID: 15599880
Document Number: 568959
Rapidly progressive glomerulonephiritis (RPGN) must be diagnosed and treated quickly to prevent irreversible organ injury. The commonest cause of RPGN is anti-neutrophil cytoplasm antibody (ANCA) associated small vessel vasculitis, and the most severe is anti-glomerular basement membrane (GBM) antibody disease. In this review we address pathogenesis, diagnosis, treatment and outcome in these two entities, with emphasis on novel therapies.

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