Adrenal myelolipoma. 6 cases and a review of the literature
Wagnerová, H.; Lazúrová, I.; Bober, J.; Sokol, L.; Zachar, M.
Neoplasma 51(4): 300-305
2004
ISSN/ISBN: 0028-2685 PMID: 15254662 Document Number: 568589
Adrenal myelolipoma is an uncommon, benign and hormonally inactive tumor. Most lesions are asymptomatic and usually are discovered incidentally at autopsy studies. Authors report oil 6 patients (5 women, 1 man) with adrenal myelolipomas (5 right, 1 left), analyze their morphological findings and association with an adrenal hormonal overproduction. Five of the patients underwent surgery because of tumor size, in 3 of them histological evaluation confirmed myelolipoma and in 2 cases an adrenocortical adenoma with foci of myelolipoma. All the patients were asymptomatic and in 4 cases hormonal overproduction was not found. One female patient has oveproduction of dehydroepiandrosteron-sulphate (DHEAS) indicating a 3beta hydroxylase deficiency in this tumor and 1 patient has primary aldosteronism with a histological finding of an association of adrenocortical adenoma with foci of myelolipoma. Neither Cushing's syndrome nor congenital adrenal hyperplasia were present in our group of patients.