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Effects of experimental varicocele on mitochondria calcium and cytochrome C of the epididymis in adolescent rats

Ma, X.; Wang, S.; Wang, Y.; Wang, S.; Wang, W.; Zhang, J.; Li, Y.

Zhonghua Nan Ke Xue 10(6): 420-422

2004

ISSN/ISBN: 1009-3591
PMID: 15267203
Document Number: 568183
To investigate the effects of experimental varicocele on mitochondria calcium and cytochrome C of the epididymal cells in adolescent rats. Forty male adult Wistar rats were divided into two groups randomly: varicocele group (VG) and sham operation group (SOG) by partial ligation or exposure of the left renal vein. Bilateral epididymides were removed after ten The content of mitochondria weeks. Mitochondria calcium and cytochrome C levels of the epididymal cells were detected. calcium decreased (P < 0.001 ) while that of cytochrome C increased (P < 0.05) markedly in the experimental group compared with SOG. Calcium dyshomeostasis and mitochondrial damage of the epididymal cells caused by varicocele may play an important role in leading to subfertility.

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Ma, X.; Wang, S.; Wang, Y.; Wang, S.; Wang, W.; Zhang, J.; Li, Y. 2004: Effects of experimental varicocele on mitochondria calcium and cytochrome C of the epididymis in adolescent rats Zhonghua Nan Ke Xue 10(6): 420-422
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