SREBP contributes to induction of collagen VI transcription by serum starvation
Ferrari, A.; Maretto, S.; Girotto, D.; Volpin, D.; Bressan, G.M.
Biochemical and Biophysical Research Communications 313(3): 600-605
2004
ISSN/ISBN: 0006-291X PMID: 14697233 Document Number: 568027
Collagen VI is a main extracellular matrix protein whose mutation is linked to myopathic diseases. In myoblasts and other cell types, collagen VI gene transcription peaks during cell-cycle exit that precedes differentiation, upon serum withdrawal or confluence. To get insight into this transcriptional regulation, we characterized a growth arrest responsive region (GARR) in the Col6a1 promoter responsible for this effect. In this work, we identify sterol regulatory element binding protein (SREBP) as a GARR binding protein and provide evidence that SREBP contributes to induction of Col6a1 transcription in serum free conditions. Furthermore, our data unveil a previously unexpected link between extracellular matrix production and LDL signaling.