Change of dopamine transporter activity (DAT) during the action of bupropion (in depression)
Szabó, Zán.; Argyelán, Mós.; Kanyó, Bázs.; Pávics, László.; Janka, Zán.
Neuropsychopharmacologia Hungarica a Magyar Pszichofarmakologiai Egyesulet Lapja 6(2): 79-81
2004
ISSN/ISBN: 1419-8711 PMID: 15787205 Document Number: 567421
Bupropion has an antidepressant effect through blocking the dopamine transporter. By 99mTc-TRODAT-SPECT, we measured the baseline DAT activity of depressed patients. After 3 weeks' bupropion treatment we studied the change in DAT activity, which corresponds to the occupancy of bupropion. The average occupancy of bupropion on DAT was similar to the international findings at 20.84% in 9 depressed patients.
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