Role of the adaptins, dynamin like GTP-ases and Rab proteins in metabolic disorders and various infections
Kierczak, M.; Surmacz, L.; Wiejak, J.; Wyroba, E.
Postepy Higieny i Medycyny Doswiadczalnej 57(6): 727-737
2003
ISSN/ISBN: 0032-5449 PMID: 15002167 Document Number: 566326
Numerous metabolic and genetic diseases are due to mutations in adaptins, dynamin-like GTP-ases or disorders in trafficking machinery mediated by Rab proteins. A great number of pathogenes including viruses (HIV, SIV), bacteria and protozoa use various elements of endocytic/trafficking machinery to get into the host cells and to make their infection successful. Their different strategies are discussed.
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