The role of lipid metabolism disorders in kidney disease in metabolic syndrome associated with obesity
Kriachkova, A.A.; Savel'eva, S.A.; Kutyrina, I.M.
Terapevticheskii Arkhiv 83(8): 54-58
2011
ISSN/ISBN: 0040-3660 PMID: 21961334 Document Number: 655702
To study the role of lipid metabolism impairment in renal disease in patients with metabolic syndrome associated with obesity. Lipid metabolism was studied in 77 patients with metabolic syndrome (MS) aged from 17 to 63 years (mean age 48 +/- 9 years). Lipid abnormalities were analysed in groups of patients with different degree of obesity: group 1 - body mass index (BMI) 25-29.9 kg/m2 (n = 13), group 2 - BMI 30-39.9 kg/m2 (n = 49), group 3 - BMI > 40 kg/m2 (n = 15), and in groups of patients with different insulin resistance (IR) : group 1 - HOMA-IR < 2; n = 12; group 2 - HOMA-IR 2 - 4; n = 27; group 3 HOMA-IR > 4; n = 32). Correlation between plasma lipid composition abnormalities and markers of renal disease were studied with correlation analysis. Lipid disbolism in MS patients was characterized with elevated level of triglycerides, total cholesterol (TC), VLDLP cholesterol, low level of HDLP cholesterol. A significant relationship was detected between defective blood lipid composition and renal dysfunction: rise of microalbuminuria, proteinuria, creatinin, inhibition ofglomerular filtration rate. The changes found characterize lipid metabolism disorder as an independent factor of kidney disease in patients with MS.