Premedication with Midazolam (Dormicum) compared with Promethazine, Droperidol and placebo in relieving anxiety using Beck's anxiety inventory
Jalbout, N.; Karam, A.N.; Karam, E.; Feghaly, C.; Khalaf, H.
Le Journal Medical Libanais. Lebanese Medical Journal 42(2): 69-73
1994
ISSN/ISBN: 0023-9852 PMID: 7616557 Document Number: 5645
In a randomized double-blind study, Midazolam (Dormicum) (7.5 mg) was compared with Promethazine (Phenergan) (25 mg), Droperidol (2.5 mg) and placebo as premedication for 98 pre-selected patients undergoing surgery. The anxiolytic effect of the above drugs was monitored by Beck's Anxiety Inventory. 83.3% of patients who received Midazolam had a decrease in their anxiety state compared to 55.6% for Promethazine, 12% for Droperidol and 25% for placebo. The study clearly proved that Midazolam is a better anxiolytic drug compared to Droperidol and Promethazine.
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