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Study on tumor necrosis factor-alpha and interleukin 2 in rat skin allograft

Wang, J.; Jin, Y.; Liu, X.

Hua Xi Kou Qiang Yi Xue Za Zhi 21(6): 471

2003

ISSN/ISBN: 1000-1182
PMID: 14732985
Document Number: 563742
To elucidate the histocompatibility of tissue engineered rat skin through studying the effect of TNF-alpha and IL-2 in immunological rejection after rat skin allograft. Tissue engineered skin that the basic materials were taken from neonatal SD rats was cultured in lab, grafted to adult Wistar rats. The expressions of TNF-alpha and IL-2 in grafted tissue were detected with immunohistochemical staining and Western blot. The expressions of TNF-alpha and IL-2 were remarkable in skin allograft group, but low in tissue engineered skin group. The expressions of TNF-alpha and IL-2 and the immunological rejection were closely related after skin allograft, but the tissue engineered skin has favorable histocompatibility and doesn't arose obvious immunological rejections.

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