Primary systemic therapy (PST) of locally advanced breast cancer using Doxorubicin/Docetaxel combination
Dank, M.; Zergenyi, E.; Domotori, Z.S.; Lahm, E.; Kulka, J.
Anticancer Research 23(3c): 2879-2880
2003
ISSN/ISBN: 0250-7005 PMID: 12926127 Document Number: 563239
Background: PST of locally advanced breast carcinomas causes tumour shrinkage and down-staging, therefore, optimal circumstances for surgery. Patients and Methods: We treated 25 stage IIIA-IIIB breast cancer patients with PST (Doxorubicin/Docetaxel). Histological diagnosis (core biopsy) was available in each case. Tumour regression and cardiac function were recorded regularly. Results: Five patients showed complete pathological remission. Instead of 19 mastectomies, only nine were performed and 16 patients underwent breast-conserving therapy. Conclusion: Using PST breast conservation rate is improved.