Serum CA-125 tumor marker in endometrial adenocarcinoma
Kukura, V.; Zovko, G.; Ciglar, S.; Markulin-Grgić, L.; Santek, F.; Podgajski, M.; Duić, Z.
European Journal of Gynaecological Oncology 24(2): 151-153
2003
ISSN/ISBN: 0392-2936 PMID: 12701966 Document Number: 562531
One hundred and seventy-four patients, mean age 61.23 +/- 9.41 years old, with irregular perimenopausal haemorrhage were included in the study. Fractional curettage was performed in all patients. When the pathohistologic findings were adenocarcinoma the concentration of CA-125 tumor marker was determined. Hysterectomy with bilateral salpingo-oophorectomy was determined. In 142 cases carcinoma was restricted to the uterus and in 32 patients extrauterine metastatic disease was found. In the former group CA-125 was positive in 130 patients with a mean value of 64.12 +/- 22.41 U/ml serum. In the latter group the cancer antigen was positive in 29 patients with a mean value of 244.82 +/- 68.11 U/ml. High production is associated with increased metastatic potential.