Significance of the cellular infiltrate at the host-tumor borderline in endometrial adenocarcinoma
Shapira, I.; Griffel, B.
Harefuah 106(11): 490-492
1984
ISSN/ISBN: 0017-7768 PMID: 6479701 Document Number: 239293
The cellular infiltrate at the host-tumor borderline in endometrial carcinoma was significantly related to the prognosis (P = 0.0042) and to the penetration of the uterine wall by tumor (P = 0.0194). The important cells from the quantitative point of view were the lymphocytes (P = 0.0002). The number of cells in the entire infiltrate including lymphocytes, monocytes and plasma cells should be taken into consideration. The cellular infiltrate was not significantly related to age of patient at diagnosis, age at onset of menopause, country of origin, grade and clinical stage of tumor and whether or not the uterus had been irradiated preoperatively. In endometrial adenocarcinoma, as perhaps in other neoplasms, there could be a cell-mediated immune response and immune reactions may either suppress or enhance tumor growth.