Study on the immuno-effects of recombinant hepatitis B vaccination in adults
Zhang, F.-m.; Zhao, Q.-x.; Han, J.-h.; Zhou, Q.-h.; Wang, M.-c.; Miao, W.; Li, R.
Zhonghua Liu Xing Bing Xue Za Zhi 24(8): 697-699
2003
ISSN/ISBN: 0254-6450 PMID: 14521791 Document Number: 562473
To evaluate the immuno-effects of hepatitis B (HB) vaccination in adults. Five groups were sampled by means of cluster sampling, and serum HBsAg, anti-HBs and anti-HBc were tested in every group at people aged from 18 to 50. Recombinant HB vaccine was injected to the ones that HBsAg, anti-HBs and anti-HBc were all negative. Concentration of anti-HBs in serum was tested after one year and three years of vaccination. Immuno-effects of recombinant HB vaccination in adults at different ages and between sexes, were then calculated. Good immuno-effects of recombinant HB vaccination in adults were noticed. After one year and three years of vaccination with 5 micro g recombinant HB vaccine, the anti-HBs positive rates were 82.76%, 70.77% while the serum concentrations of anti-HBs were 55.91 mIU/ml and 35.41 mIU/ml respectively. When 10 micro g was used, the concentrations were 83.74%, 72.22%, 56.89 mIU/ml and 30.29 mIU/ml respectively. The effects did not show significant differences between different doses on 10 micro g and of 5 micro g. Concentration of anti-HBs reduced when time went by. The factors such as age and sex influenced the effects of immunity on recombinant HB vaccination. Good immunity could be obtained when recombinant hepatitis B was vaccinated in vulnerable population aged 18 to 50.