Phosphate prodrugs of isophosphoramide mustard
Misiura, K.; Szymanowicz, D.; Wietrzyk, J.; Opolski, A.
Acta Poloniae Pharmaceutica 60(2): 109-112
2003
ISSN/ISBN: 0001-6837 PMID: 13678316 Document Number: 562452
Dibenzylphosphorobenzyl and phosphorobenzyl analogues of isophosphoramide mustard, an active metabolite of ifosfamide were synthesized. Phosphorobenzyl analogue posseses stronger cytotoxic activity than isophosphoroamide mustard against the cells of several cancer cell lines suggesting the possibility of the use of this compound in Gene-Directed Enzyme-Prodrug Therapy (GDEPT).
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