Thymidylate synthase gene polymorphism and its association with relapse in childhood B-cell precursor acute lymphoblastic leukemia
Lauten, M.; Asgedom, G.; Welte, K.; Schrappe, M.; Stanulla, M.
Haematologica 88(3): 353-354
2003
ISSN/ISBN: 0390-6078 PMID: 12651279 Document Number: 562445
We investigated a tandem-repeat polymorphism within the promoter region of the thymidylate synthase gene in 40 matched pairs of relapsed and non-relapsed childhood B-cell precursor acute lymphoblastic leukemia patients. This polymorphism has previously been suggested to influence treatment outcome in childhood acute lymphoblastic leukemia. In our study, no association between thymidylate synthase genotype and risk of relapse was found.
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