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The protection of seed oil of Hippophae rharmnoides on ischemic cerebral infarction in rats

Cheng, T.-j.; Wang, Y.-b.; Gao, L.-p.; Sun, Y.-f.; Zhang, J.

Zhongguo Zhong Yao Za Zhi 28(6): 548-550

2003

ISSN/ISBN: 1001-5302
PMID: 15015338
Document Number: 562009
To study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action. Focal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI). Seed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats. These results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.

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