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Novel regulation of insulin secretion: the role of mitochondria

Maechler, P.

Current Opinion in Investigational Drugs 4(10): 1166-1172

2003

ISSN/ISBN: 1472-4472
PMID: 14649207
Document Number: 561884
Coupling of glucose entry to insulin secretion in pancreatic beta-cells depends on numerous intracellular metabolic steps. In this process, mitochondria play a central role, and defects in this organelle are associated with impaired glucose-evoked insulin release. In response to a glucose rise, nucleotides and metabolites are generated by mitochondria and participate, together with cytosolic Ca2+, in the stimulation of insulin exocytosis. This review describes the mitochondria-dependent pathways of regulated insulin secretion. In addition, new potential drug targets for therapeutic interventions in diabetes are discussed.

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