Antiischemic efficacy of trimetazidine in patients with intermittent claudication and effort angina
Syrkin, A.L.; Artiukhina, E.G.; Kanorskiĭ, S.G.; Chuntyzheva, M.M.
Kardiologiia 43(7): 49-52
2003
ISSN/ISBN: 0022-9040 PMID: 12891299 Document Number: 561809
Male patients (n=42) with atherosclerosis obliterans and stage IIA-III ischemia of lower extremities combined with class II-III angina pectoris were divided into 2 groups. Patients of group 1 (n=21) were given simvastatin (10-20 mg/day), clopidogrel (75 mg/day) and trimetazidine (60 mg/day) for 6 months, those of group 2 - simvastatin and clopidogrel also for 6 months. Statistically significant decreases of frequency of attacks of angina, nitroglycerine consumption and increases of walking distance occurred only in group 1.