Immunising the HIV-infected child: a view from sub-Saharan Africa
Mphahlele, M.J.; Mda, S.
Vaccine 30(Suppl 3): C61-C65
2012
ISSN/ISBN: 1873-2518 PMID: 22939024 DOI: 10.1016/j.vaccine.2012.02.040Document Number: 561471
The HIV-infected children are prone to multitude of infections. In sub-Saharan Africa, HIV/AIDS is certainly an important acquired immunodeficiency and is more likely to negatively impact on immunisation programmes than other forms of immunodeficiencies. Although HIV infection is generally not a contra-indication for immunisation, high background HIV prevalence in the region may result in lower rates of vaccine immunogenicity, efficacy and population immunity. Nevertheless, vaccination is still better than natural infection; the risk of vaccination far outweighs the risk of infection with the pathogen. The primary focus of this review is to discuss the lessons learned in vaccinating HIV-infected children particularly with key live-attenuated vaccines in Africa such as Bacille Calmette-Guérin (BCG), measles, oral polio vaccine (OPV), yellow fever and rotavirus. Immunisation against influenza virus, a common cause of respiratory illness, is also discussed as multiple guidelines recommend influenza vaccination for number of groups at high risk such as patients infected with HIV.
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