Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes
Kilewo, C.; Natchu, U.C.M.; Young, A.; Donnell, D.; Brown, E.; Read, J.S.; Sharma, U.; Chi, B.H.; Goldenberg, R.; Hoffman, I.; Taha, T.E.; Fawzi, W.W.
African Journal of Reproductive Health 13(4): 25-36
2009
ISSN/ISBN: 1118-4841 PMID: 20690271 Document Number: 213817
This analysis was performed to determine the prevalence of hypertension and association of MAP (mean arterial pressure) with birth outcomes among HIV-infected pregnant women not taking antiretrovirals. HIV-infected pregnant women, enrolled into the HPTN024 trial in Tanzania, Malawi and Zambia were followed up at 26-30, 36 weeks, and delivery. The prevalence of hypertension was <1% at both 20-24 weeks and 26-30 weeks and 1.7% by 36 weeks. A 5 mm Hg elevation in MAP increased the risk of stillbirth at 20-24 weeks by 29% (p = 0.001), 32% (p = 0.001) at 26-30 weeks and of low birth weight (LBW) at 36 weeks by 26% (p = 0.001). MAP was not associated with stillbirth at 36 weeks, LBW prior to 36 weeks, preterm birth, neonatal mortality or the risk of maternal to child transmission (MTCT) of HIV.