Almotriptan: an effective and well-tolerated treatment for migraine pain
Pascual, J.
Drugs of Today 39 Suppl D: 31-36
2003
ISSN/ISBN: 1699-3993 PMID: 15071618 Document Number: 560722
The clinical data of almotriptan, the new selective 5-HT(1B/1D) agonist developed for the symptomatic treatment of migraine, are reviewed here. The pharmacokinetic performance of almotriptan is compared with that of other currently available triptans. The dose exhibiting the best efficacy/tolerability ratio of almotriptan is 12.5 mg. Efficacy of this almotriptan dose is comparable to that of the "gold" standard triptan, but with a lower recurrence rate. Gender or the presence of food in the stomach does not influence almotriptan's pharmacokinetic profile, and no relevant interactions of almotriptan with other medications have been reported. The tolerability of almotriptan is similar to that of placebo. Almotriptan's high efficacy together with its excellent tolerability and safety profile confirm this new 5-HT(1B/1D) agonist as a drug of choice for the symptomatic treatment of migraine attacks.