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Gene expression profile changes in human multiple myeloma

Shi, Y-wu.; Hu, W-xin.; Tang, L-jun.

Hunan Yi Ke Da Xue Xue Bao 28(3): 201-205

2003

ISSN/ISBN: 1000-5625
PMID: 14653065
Document Number: 560216
Objective: To determine the difference in gene expression between human multiple myeloma (MM) and normal bone marrow. Methods: cDNA chip was used to detect the mRNA of mononuclear cell from 10 untreated MM patients and 10 cases of normal bone marrow. Results: Of the 2 048 genes, we found 566 different expression genes, of which the expression of 237 genes was higher and 329 lower in MM than in the normal bone marrow. Conclusion: Many genes may be involved in the pathogenesis of MM. cDNA chip technology is an effective tool in the study of tumor related genes.

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