Enzymatic activity and therapeutic action of pepsin K in chronic gastritis with secretory failure
Kharitonin, V.V.; Chernenko, G.T.; Sdobnova, E.A.; Khliabich, A.G.
Klinicheskaia Meditsina 81(8): 35-37
2003
ISSN/ISBN: 0023-2149 PMID: 14520943 Document Number: 559527
Pepsin K (chicken pepsin) in the test for hemoglobin proteolysis is 1.7 times superior to abomin (porcine pepsin) in the medium pH 2 and 44 times more potent in the medium pH 3. Even in pH 4 chicken pepsin retains its enzymatic activity while porcine pepsin in pH 4 looses its activity. These biochemical findings show that pepsin K is more effective in the treatment of enzymatic insufficiency of the stomach. Intake of 1-3 pepsin K tablets after meal for 4 weeks by 82 patients having chronic gastritis with secretory insufficiency was effective in 75% of patients.