Top Abstract Purchase Related
Home
>
Node
>
Subnode

Single-cell irradiation from [211At] astatine-labeled C215 monoclonal antibody: improved estimates of radiosensitivity from measurements on cellular uptake and retention

Palm, S.; Bäck, T.; Claesson, I.; Delle, U.; Hultborn, R.; Lindegren, S.; Jacobsson, L.

Anticancer Research 23(2b): 1219-1221

2003

ISSN/ISBN: 0250-7005
PMID: 12820374
Document Number: 559490
New data on the biological effect of 211At-C215 monoclonal antibody in a slowly rotating, widely dispersed single-cell suspension of the human cancer cell line Colo-205 is presented. Cell growth curves of each experiment were used to calculate an apparent cell survival after irradiation. Uptake measurements provided the data needed to calculate the average number of 211At decays per cell in the cell suspension. The results from each experiment were then fit to a mono-exponential function. From the exponential fit, an average of 35 +/- 2 (SD) astatine-211 decays per cell are required for 37% apparent cell survival (D0).

Document emailed within 1 workday
Secure & encrypted payments

Blend, M.J.; Hyun, H.; Kozloff, M.; Levi, H.; Mills, G.Q.; Gasparini, M.; Buraggi, G.; Hughes, L.; Pinsky, C.M.; Goldenberg, D.M. 1995: Improved staging of B-cell non-Hodgkin's lymphoma patients with 99mTc-labeled LL2 monoclonal antibody fragment Cancer Research 55(23 Suppl): 5764s-5770s
Jones, P.L.; Brown, B.A.; Sands, H. 1990: Uptake and metabolism of 111In-labeled monoclonal antibody B6.2 by the rat liver Cancer Research 50(3 Suppl): 852s-856s
Juhl, H.; Sievers, M.; Baltzer, K.; Helmig, F.; Wolf, H.; Brenner, W.; Kalthoff, H. 1995: A monoclonal antibody-cobra venom factor conjugate increases the tumor-specific uptake of a 99mTc-labeled anti-carcinoembryonic antigen antibody by a two-step approach Cancer Research 55(23 Suppl): 5749s-5755s
Macey, D.J.; Denardo, S.J.; Denardo, G.L.; Goodnight, J.K.; Unger, M.W. 1988: Uptake of indium-111-labeled monoclonal antibody ZME-018 as a function of tumor size in a patient with melanoma American Journal of Physiologic Imaging 3(1): 1-6
Kairemo, K.J.; Himi, T.; Hopsu, E.V.; Ramsay, H.A. 1997: Radioimmunoimaging of glomus tympanicum tumors by In-111 labeled monoclonal antibody using single photon emission computed tomography American Journal of Otology 18(6): 750-753
Intrarapuk, A.; Awakairt, S.; Thammapalerd, N.; Mahannop, P.; Pattanawong, U.; Suppasiri, T. 2001: Comparison between R-phycocyanin-labeled and R-phycoerythrin-labeled monoclonal antibody (Mab) probes for the detection of Entamoeba histolytica trophozoites Southeast Asian Journal of Tropical Medicine and Public Health 32(Suppl 2): 165-171
Sands, H.; Jones, P.L.; Shah, S.A.; Palme, D.; Vessella, R.L.; Gallagher, B.M. 1988: Correlation of vascular permeability and blood flow with monoclonal antibody uptake by human Clouser and renal cell xenografts Cancer Research 48(1): 188-193
Tanphaichitra, D.; Srimuang, S. 1984: Cellular immunity (T-cell subset using monoclonal antibody) in tuberculosis, melioidosis, pasteurellosis, penicilliosis; and role of levamisole and isoprinosine Developments in Biological Standardization 57: 117-123
Sugiyama, Y.; Chen, F.A.; Takita, H.; Bankert, R.B. 1988: Selective growth inhibition of human lung cancer cell lines bearing a surface glycoprotein gp160 by 125I-labeled anti-gp160 monoclonal antibody Cancer Research 48(10): 2768-2773
Bradley, T.P.; Bonavida, B. 1982: Mechanism of cell-mediated cytotoxicity at the single cell level. IV. Natural killing and antibody-dependent cellular cytotoxicity can be mediated by the same human effector cell as determined by the two-target conjugate assay Journal of Immunology 129(5): 2260-2265
Sung, C.; Shockley, T.R.; Morrison, P.F.; Dvorak, H.F.; Yarmush, M.L.; Dedrick, R.L. 1992: Predicted and observed effects of antibody affinity and antigen density on monoclonal antibody uptake in solid tumors Cancer Research 52(2): 377-384
Kusakabe, K.; Yamazaki, T. 1985: Radionuclide imaging with labeled monoclonal antibody Nihon Rinsho. Japanese Journal of Clinical Medicine 43(4): 860-869
Shimodaira, H.; Komine, K.; Soeda, H.; Ishioka, C. 2010: Antibody-dependent cellular cytotoxicity in the immunotherapeutic mechanisms of anti-EGFR monoclonal antibody Gan to Kagaku Ryoho. Cancer and ChemoTherapy 37(5): 795-798
Zhao, X.-l.; Sun, W.-r.; Sun, X.-l.; Jiang, T. 2006: Production and characterization of gold labeled monoclonal antibody against MC-LR Wei Sheng Yan Jiu 35(4): 442-445
Ruegg, C.L.; Anderson-Berg, W.T.; Brechbiel, M.W.; Mirzadeh, S.; Gansow, O.A.; Strand, M. 1990: Improved in vivo stability and tumor targeting of bismuth-labeled antibody Cancer Research 50(14): 4221-4226
Dudczak, R.; Kletter, K.; Bailer, H.; Kokoschka, E.; Pohl-Markl, H. 1987: Immunoscintigraphy with a technetium 99m-labeled monoclonal antibody in patients with melanoma Wiener Klinische Wochenschrift 99(7): 232-239
McIlwrath, A.J.; Vasey, P.A.; Ross, G.M.; Brown, R. 1994: Cell cycle arrests and radiosensitivity of human tumor cell lines: dependence on wild-type p53 for radiosensitivity Cancer Research 54(14): 3718-3722
Major, P.P.; Dion, A.S.; Williams, C.J.; Mattes, M.J.; Wang, T.; Rosenthall, L. 1990: Breast tumor radioimmunodetection with a 111In-labeled monoclonal antibody (MA5) against a mucin-like antigen Cancer Research 50(3 Suppl): 927s-931s
Schlom, J.; Siler, K.; Milenic, D.E.; Eggensperger, D.; Colcher, D.; Miller, L.S.; Houchens, D.; Cheng, R.; Kaplan, D.; Goeckeler, W. 1991: Monoclonal antibody-based therapy of a human tumor xenograft with a 177lutetium-labeled immunoconjugate Cancer Research 51(11): 2889-2896
Matsumura, H.; Otsuji, E.; Kobayashi, S.; Okamoto, K.; Toma, A.; Yamagishi, H. 2001: Potential usefulness of 99mTc-labeled monoclonal antibody A7 for immunoscintigraphy of human pancreatic carcinoma Anticancer Research 21(5): 3433-3437