Vasculogenesis and angiogenesis: molecular and cellular controls. part I: growth factors
Kubis, N.; Levy, B.I.
Morphologie Bulletin de l'Association des Anatomistes 87(276): 23-30
2003
ISSN/ISBN: 1286-0115 PMID: 12793111 Document Number: 557765
Angiogenesis characterizes embryonic development, but occurs also in adulthood, under physiological circumstances like adaptation to muscular exercise or in pathology like cancers. Knowledge of these mechanisms has step forward partly due to knock-out mice that have allowed to devoid an exact role to the different growth factors that are involved. Interestingly, the same growth factors and their receptors are equally involved during development and adulthood. We have detailed here their respective role and how interactions between them leads to a newly formed vessel.