Cell lineage assignment of cytogenetic findings in acute lymphoblastic leukemia using combined immunomagnetic cell separation and chromosome preparation
Rieder, H.; Bachmann, I.; Busch, S.; Schwartz, S.; Reckzeh, B.; Hoelzer, D.
Haematologica 88(11): 1317-1320
2003
ISSN/ISBN: 0390-6078 PMID: 14607762 Document Number: 556903
In acute lymphoblastic leukemia (ALL) abnormal karyotypes frequently constitute a minor part of the dividing cells, and the origin of metaphases in normal diploid cases remains obscure. We used a combination of immunomagnetic cell separation and chromosome preparation (ICSCP) to focus on the metaphases of interest and to assign the chromosome findings to CD19+ or CD7+ leukemia cells.
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