Results of a prospective randomized investigation [Russia (St.Petersburg) /WHO] to evaluate the significance of self-examination for the early detection of breast cancer
Semiglazov, V.F.; Manikhas, A.G.; Moiseenko, V.M.; Protsenko, S.A.; Kharikova, R.S.; Seleznev, I.K.; Popova, R.T.; Migmanova, N.S.; Orlov, A.A.; Barash, N.I.; Ivanova, O.A.; Ivanov, V.G.
Voprosy Onkologii 49(4): 434-441
2003
ISSN/ISBN: 0507-3758 PMID: 14569932 Document Number: 556637
Indications for puncture or excision biopsy were significantly higher in the study group (7.5%) as compared with control (3.5%) (p < 0.01) in a randomized prospective controlled trial of a comprehensive breast cancer screening (123,748) carried out in the framework of a self-examination education program. In the self-examination group, detection rates were higher both for benign (1.1%) and malignant (0.85%) tumors than in control (0.5% and 0.69%, respectively) (p < 0.05). Early stage (T1NOMO, Tis) distribution difference in the study group and controls was insignificant--23 and 17.6%, respectively. Compliance with the program requirements including monthly or bimonthly self-examination was followed by higher 15-year survival rates (53.2%) in 70-75% as compared with controls(45.8%) (p = 0.05105): yet it did not affect mortality.