Doramectin toxicity in a collie
Yas-Natan, E.; Shamir, M.; Kleinbart, S.; Aroch, I.
Veterinary Record 153(23): 718-720
2003
ISSN/ISBN: 0042-4900 PMID: 14690080 Document Number: 556393
A seven-year-old intact collie, weighing 30 kg, was presented at the Hebrew University Teaching Hospital with a history of aimless walking, behavioural changes and apparent blindness. The dog had been given a subcutaneous injection of doramectin (Dectomax) at a rate of 200 micro g/kg body weight 48 h prior to presentation in another clinic. Initial clinical signs including restlessness and apparent loss of vision were observed 24 h after treatment. Dexamethasone was given at the first clinic, however, the dog's condition deteriorated over the last 24 h. At the Teaching Hospital the condition was tentatively diagnosed as doramectin toxicosis, and supportive therapy with lactated Ringer's solution (150 ml/h, i.v.), amoxicillin-clavulanic acid (Augmentin, 15 mg/kg body weight), and oxygen via intranasal tube (1 litre/min) was provided. The dog did not display any improvement in condition until the 4th day of hospitalization, when it was finally able to stand but with support, and had regained appetite but ate with assistance. The dog was discharged on the 6th day of hospitalization when it was capable of eating unassisted, despite apparent signs of ataxia. The dog was judged to be clinically normal 16 days after being discharged from the hospital.